Description

N2-Methyl-L-Arginine is a high-purity, modified amino acid derivative of L-Arginine, featuring a methyl group on the terminal guanidino nitrogen. This specific methylation is critical for biochemical research, particularly in the study of protein function, enzyme inhibition, and nitric oxide synthase pathways. It serves as a valuable building block and reference standard for pharmaceutical R&D, proteomics, and metabolic studies. Key industries that utilize this compound include advanced life science research, contract manufacturing organizations (CMOs), and developers of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate analog and inhibitor in enzymatic studies, particularly for nitric oxide synthase (NOS) and protein arginine methyltransferases (PRMTs).
• Pharmaceutical Intermediates: Serves as a key chiral building block in the synthesis of potential drug candidates targeting cardiovascular and neurological disorders.
• Proteomics & Metabolomics: Employed as a stable isotope-labeled internal standard (e.g., 13C, 15N) for accurate mass spectrometry-based quantification in complex biological samples.
• Peptide Synthesis: Incorporated into custom peptides to study the effects of arginine methylation on protein-protein interactions, stability, and signaling.
• Reference Standard: Provides a high-purity certified material for quality control and method validation in analytical laboratories.
• Academic Research: Fundamental tool for investigating post-translational modifications, epigenetics, and cellular regulation mechanisms.

Basic Information

Product Name	N2-Methyl-L-Arginine
CAS No.	2480-28-6
Molecular Formula	C7H16N4O2
Molecular Weight	188.23 g/mol
Synonyms	ω-N-Methyl-L-arginine; L-NMMA; NG-Methyl-L-arginine; NG-Monomethyl-L-arginine; Nω-Methyl-L-arginine; Methylarginine; MMA; (S)-2-Amino-5-[(methylamino)iminomethyl]aminopentanoic acid; SD-666; L-NG-Monomethylarginine
EINECS	219-617-7

Quality Control

Our N2-Methyl-L-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and MS. We provide full traceability and Certificates of Analysis (COA) that detail all test results against stringent in-house specifications. The product is suitable for research and development applications requiring high chemical and isomeric purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: +22.0° to +26.0° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.