Description

L-Proline, 4-Hydroxy-1-Nitroso-, cis- (9Ci) CAS NO 2443-31-4 is a specialized, high-purity derivative of the amino acid proline, characterized by its unique cis-configuration and functional nitroso and hydroxyl groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of novel molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry, asymmetric synthesis, and the creation of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery programs.
• Asymmetric Synthesis: Utilized as a precursor or catalyst component in stereoselective reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space for therapeutic agents.
• Agrochemical Development: Serves as an intermediate in the synthesis of advanced, biologically active compounds for crop protection.
• Biochemical Research: Used in the study of enzyme mechanisms and protein interactions where modified amino acid probes are required.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of custom-designed compounds in contract research and manufacturing.

Basic Information

Product Name	L-Proline, 4-Hydroxy-1-Nitroso-, cis- (9Ci)
CAS No.	2443-31-4
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	cis-4-Hydroxy-1-nitrosoproline; (2S,4R)-4-Hydroxy-1-nitrosopyrrolidine-2-carboxylic acid; 1-Nitroso-4-hydroxy-L-proline; L-1-Nitroso-4-hydroxyproline; 4-Hydroxy-1-nitrosoproline; 1-Nitroso-4-hydroxyproline; cis-1-Nitroso-4-hydroxy-L-proline; 4-Hydroxy-1-nitrosoproline, cis-
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-1-Nitroso-, cis- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to meet the exacting standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.