Description

Boc-Gln-Pro-Oh CAS NO 2419-99-0 is a protected tripeptide derivative, specifically Nα-(tert-Butoxycarbonyl)-L-glutaminyl-L-proline, widely used as a crucial building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a protected glutamine residue, preventing unwanted side reactions during the assembly of complex peptide chains. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of novel therapeutic peptides and peptidomimetics targeting various diseases.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/t-Boc chemistry protocols to incorporate a protected glutamine residue into custom peptide sequences.
• Biochemical Research: Serves as a standard or reagent in studies of enzyme substrates, inhibitors, and protein-protein interactions.
• Combinatorial Chemistry: Employed in libraries for drug discovery to create diverse arrays of peptide-based compounds for screening.
• Peptide Hormone Analog Development: A precursor in the research and production of analogs for metabolic and endocrine research.
• Cosmeceutical Peptide Synthesis: Potential use as an intermediate for bioactive peptides in advanced skincare formulations.

Basic Information

Product Name	Boc-Gln-Pro-Oh
CAS No.	2419-99-0
Molecular Formula	C₁₆H₂₇N₃O₇
Molecular Weight	373.40 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutaminyl-L-proline; Boc-L-Gln-L-Pro-OH; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-4-carbamoylbutanamido)pyrrolidine-1-carboxylic acid; Nα-Boc-L-glutaminyl-L-proline; Boc-Gln-Pro; BOC-GLN-PRO-OH; t-Boc-Gln-Pro-OH; N-tert-Butoxycarbonylglutaminylproline
EINECS	Contact for details

Quality Control

Our Boc-Gln-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-50.0° to -55.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.