Description

Z-Trp-Leu-Oh CAS NO 2419-35-4 is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of the Tryptophan-Leucine dipeptide. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), offering precise control over peptide chain assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel therapeutic peptides and conducting biochemical research.

Application

• Pharmaceutical Intermediates: A key raw material for the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid coupling unit for the controlled, sequential construction of custom peptide sequences.
• Biochemical Research: Used in academic and industrial laboratories to study peptide structure, function, and interactions.
• Proteomics & Drug Discovery: Employed in the development of peptide libraries for high-throughput screening and identifying new drug candidates.
• Bioconjugation: Acts as a precursor for creating peptide tags or linkers used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Cosmeceutical Peptides: A potential intermediate for synthesizing bioactive peptides used in advanced skincare formulations.

Basic Information

Product Name	Z-Trp-Leu-Oh
CAS No.	2419-35-4
Molecular Formula	C25H29N3O5
Molecular Weight	451.52 g/mol
Synonyms	N-Carbobenzyloxy-L-tryptophyl-L-leucine; Z-L-Tryptophyl-L-leucine; Z-Trp-Leu; CBZ-L-Tryptophyl-L-leucine; Nα-CBZ-L-Tryptophyl-L-leucine; (S)-2-(((S)-1-((Benzyloxy)carbonyl)-2-(1H-indol-3-yl)ethyl)amino)-4-methyl-1-oxopentan-1-oic acid; L-Leucine, N-[(benzyloxy)carbonyl]-L-tryptophyl-; Z-L-Trp-L-Leu-OH
EINECS	Contact for details

Quality Control

Our Z-Trp-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and cGMP-grade requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-20° to -25° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.