Description

2,4-Difluorobenzyl Bromide is a versatile and high-purity organic building block essential for advanced chemical synthesis. This compound matters because it serves as a critical intermediate for introducing the difluorobenzyl moiety, a key structural feature known to enhance metabolic stability and binding affinity in active pharmaceutical ingredients. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the difluorobenzyl group imparts desired biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated organic electronic materials for displays and lighting.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Nucleophilic Substitution: Reacts with various nucleophiles (amines, thiols, alkoxides) to create diverse benzyl derivatives for further functionalization.
• Chemical Research & Development: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2,4-Difluorobenzyl Bromide
CAS No.	2391-57-3
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	α-Bromo-2,4-difluorotoluene; 1-(Bromomethyl)-2,4-difluorobenzene; (2,4-Difluorophenyl)methyl Bromide; 2,4-Difluoro-α-bromotoluene; 2,4-DFBB; Benzene, 1-(bromomethyl)-2,4-difluoro-; 2,4-Difluorobenzylbromide
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.