Description

5-Fluoro-3-Nitroaniline is a versatile aromatic amine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of its functional groups, enabling precise chemical modifications for creating complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active ingredients and functional dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Dye and Pigment Manufacturing: Serves as a starting material for synthesizing azo dyes and other complex colorants, contributing to color fastness and specific hue properties.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers and photoactive compounds.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing C-N bonds in complex molecules.
• Chemical Research & Development: Fundamental reagent for exploring new synthetic methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	5-Fluoro-3-Nitroaniline
CAS No.	2369-12-2
Molecular Formula	C6H5FN2O2
Molecular Weight	156.11 g/mol
Synonyms	3-Nitro-5-fluoroaniline; 5-Fluoro-3-nitrobenzenamine; 1-Amino-3-fluoro-5-nitrobenzene; 3-Fluoro-5-nitroaniline; Benzenamine, 5-fluoro-3-nitro-; 5-Fluoro-m-nitroaniline; 3-Amino-5-fluoronitrobenzene; 2369-12-2 (CAS)
EINECS	219-146-4

Quality Control

Our 5-Fluoro-3-Nitroaniline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92°C - 96°C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.