Description

4-Fluoro-3-(trifluoromethyl)aniline is a high-value fluorinated aromatic amine building block, essential for introducing both fluorine and aniline functionalities into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced agrochemicals, pharmaceuticals, and specialty materials where enhanced bioactivity, stability, and lipophilicity are required. This compound is primarily sought by R&D chemists and process development teams in the life sciences and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel anticancer, antiviral, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved metabolic stability and membrane permeability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Intermediate: Utilized in the manufacture of high-performance, light-fast fluorinated dyes and pigments.
• Cross-coupling Reactions: Acts as a versatile substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to create complex aniline derivatives.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)aniline
CAS No.	2357-47-3
Molecular Formula	C7H5F4N
Molecular Weight	179.12 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzenamine; 3-Trifluoromethyl-4-fluoroaniline; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluidine; 1-Amino-4-fluoro-3-(trifluoromethyl)benzene; Benzenamine, 4-fluoro-3-(trifluoromethyl)-; 4-Fluoro-3-trifluoromethylphenylamine; 4-Fluoro-3-trifluoromethylaniline; 4-Fluoro-α,α,α-trifluoro-m-toluidine
EINECS	219-107-5

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)aniline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline mass
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.