Description

2H-1,4-Benzodiazepin-2-One, 1,3-Dihydro-5-Phenyl-7-(Trifluoromethyl)- is a high-purity benzodiazepine derivative, a key structural motif in medicinal chemistry. This compound matters as a versatile and critical pharmaceutical intermediate for the research and development of active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for synthesizing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a core building block for the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for central nervous system (CNS) targets.
• Process Chemistry Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for drug candidates.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Utilized as a ligand or probe in studying GABAA receptor interactions and related neurological pathways.
• Custom Synthesis: A starting material for the custom synthesis of specialized chemical entities for preclinical and clinical studies.

Basic Information

Item	Details
Product Name	2H-1,4-Benzodiazepin-2-One, 1,3-Dihydro-5-Phenyl-7-(Trifluoromethyl)-
CAS No.	2285-16-7
Molecular Formula	C16H11F3N2O
Molecular Weight	304.27 g/mol
Synonyms	7-Trifluoromethyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-Phenyl-7-(trifluoromethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-(Trifluoromethyl)-5-phenyl-1H-1,4-benzodiazepine-2(3H)-one; Ro 07-4065; Ro 07 4065; Ro-07-4065; 1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-7-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2H-1,4-Benzodiazepin-2-One, 1,3-Dihydro-5-Phenyl-7-(Trifluoromethyl)- is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.