Description

4-Chloro-3,5-Difluorophenol is a versatile fluorinated phenolic intermediate of significant importance in advanced organic synthesis. Its unique halogenated structure makes it a critical building block for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorophenol moiety enhances biological activity and stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of high-performance polymers, such as polyarylates and polycarbonates, to impart specific thermal and chemical resistance.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the chlorodifluorophenol group into target molecules.
• Dyestuff and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments requiring halogenated phenolic components.

Basic Information

Product Name	4-Chloro-3,5-Difluorophenol
CAS No.	2268-03-3
Molecular Formula	C6H3ClF2O
Molecular Weight	164.54 g/mol
Synonyms	3,5-Difluoro-4-chlorophenol; 4-Chloro-3,5-difluorophenol; Phenol, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluoro phenol; 2268-03-3; 4-Chloro-3,5-difluoro hydroxybenzene; 1-Chloro-2,6-difluoro-4-hydroxybenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorophenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.