Description

p-Toluoyl Fluoride, Alpha,α-Difluoro- (7Ci,8Ci) is a specialized organofluorine building block characterized by its reactive difluoromethyl ketone moiety. This compound is highly valued in advanced organic synthesis for its ability to introduce fluorinated structural motifs, which are critical for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting metabolic stability and bioavailability enhancement.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where fluorine substitution can improve efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and advanced organic electronic materials.
• Fluorine Chemistry Reagent: Employed in academic and industrial R&D for studying nucleophilic substitution reactions and the synthesis of complex fluoroorganic compounds.
• PET (Positron Emission Tomography) Tracer Development: Potential use as a precursor for incorporating fluorine-18, a common radioisotope, into diagnostic imaging agents.

Basic Information

Product Name	p-Toluoyl Fluoride, Alpha,α-Difluoro- (7Ci,8Ci)
CAS No.	2251-80-1
Molecular Formula	C8H6F3O
Molecular Weight	175.13 g/mol
Synonyms	4-Methylbenzoyl Fluoride, α,α-Difluoro-; 2,2-Difluoro-1-(4-methylphenyl)ethanone; 4-Methyl-α,α-difluoroacetophenone; 1-(4-Methylphenyl)-2,2-difluoroethanone; p-Tolyl 2,2-Difluoro-1-oxoethyl Ketone; Difluoro(p-tolyl)methanone; (4-Methylphenyl)(difluoro)methanone
EINECS	Contact for details

Quality Control

Our production of p-Toluoyl Fluoride, Alpha,α-Difluoro- adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by modern analytical techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.