Description

4-(Trifluoromethoxy)Phenyl Chlorothioformate is a specialized organosulfur reagent featuring a reactive chlorothioformate group and a trifluoromethoxy-substituted aromatic ring. This compound matters as a versatile building block for introducing the S-COCl functional group, enabling the synthesis of thioesters, thiocarbamates, and other sulfur-containing derivatives with enhanced lipophilicity and metabolic stability imparted by the trifluoromethoxy moiety. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those requiring sulfur-based pharmacophores or trifluoromethoxy groups for improved bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the thiocarbonyl linkage is critical for biological activity.
• Material Science Research: Serves as a monomer or modifying agent in the development of specialty polymers and functional materials with unique surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme mechanisms, particularly those involving cysteine residues.
• Ligand and Catalyst Development: Useful for preparing sulfur-containing ligands for metal complexes used in catalysis.

Basic Information

Product Name	4-(Trifluoromethoxy)Phenyl Chlorothioformate
CAS No.	2251-66-3
Molecular Formula	C8H4ClF3O2S
Molecular Weight	256.63 g/mol
Synonyms	p-(Trifluoromethoxy)phenyl chlorothioformate; 4-(Trifluoromethoxy)benzenecarbonothioic chloride; 1-(Trifluoromethoxy)-4-(chlorothioformyl)benzene; 4-Trifluoromethoxyphenyl chlorothioformate; Phenyl chlorothioformate, 4-(trifluoromethoxy)-; Chlorothioformic acid O-[4-(trifluoromethoxy)phenyl] ester
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethoxy)Phenyl Chlorothioformate adheres to stringent quality protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.