Description

Dimethyltubocurine is a semi-synthetic derivative of the natural alkaloid tubocurarine, primarily known for its potent neuromuscular blocking activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for studying neuromuscular junction physiology and developing new anesthetic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity bioactive compounds for pharmacological studies and quality control.

Application

• Pharmaceutical Research: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development and study of neuromuscular blocking agents.
• Pharmacological Studies: Used in in vitro and in vivo research to investigate the mechanisms of action at nicotinic acetylcholine receptors.
• Analytical Chemistry: Serves as a high-purity calibration standard in HPLC, LC-MS, and other chromatographic methods for method development and validation.
• Biochemical Assays: Employed in receptor binding assays and other biochemical tests to screen for new therapeutic compounds targeting the neuromuscular junction.
• Academic Research: A vital tool in university and institutional labs for teaching and advanced research in neuropharmacology and anesthesiology.
• Quality Control: Used by API manufacturers as a system suitability standard to ensure the purity and potency of related pharmaceutical batches.

Basic Information

Product Name	Dimethyltubocurine
CAS No.	2233-44-5
Molecular Formula	C₄₀H₄₈N₂O₆ • 2Cl • 5H₂O
Molecular Weight	815.78 g/mol (for pentahydrate dichloride salt)
Synonyms	Dimethyl Tubocurarine; Dimethyl-D-tubocurarine; Metocurine; Metubine; (+)-Tubocurarine Dimethyl Ether; Dimethyltubocurarine Chloride; Dimethyltubocurarine Iodide; Mecostrin
EINECS	218-787-9

Quality Control

Our Dimethyltubocurine is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specific impurities to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤12.0% (for hydrate form)
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.