Description

4,5-Dichloroquinazoline is a high-value halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its reactive chlorine atoms enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel quinazoline-based compounds.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of tyrosine kinase inhibitors and other targeted cancer therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides with quinazoline cores.
• Material Science Research: Serves as a building block for creating organic electronic materials and photoactive compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring functionalized quinazoline derivatives.
• Academic & Industrial R&D: Fundamental research into heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	4,5-Dichloroquinazoline
CAS No.	2148-55-2
Molecular Formula	C8H4Cl2N2
Molecular Weight	199.04 g/mol
Synonyms	4,5-Dichloro-quinazoline; Quinazoline, 4,5-dichloro-; 4,5-Dichloroquinazoline; 2148-55-2; 4,5-Dichloro-quinazoline; 4,5-Dichlorbenzo[d]pyrimidine
EINECS	218-418-3

Quality Control

Our 4,5-Dichloroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.