Description

4-Fluoroaniline Hcl CAS NO 2146-07-8 is a halogenated aniline derivative that serves as a critical fluorinated building block in advanced organic synthesis. Its primary value lies in introducing the fluorine atom and aniline functionality into target molecules, enabling the fine-tuning of physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, antibacterial, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine moiety enhances biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a precursor for fluorinated dyes and pigments, contributing to color fastness and unique optical properties.
• Liquid Crystal & OLED Materials: A valuable intermediate in the synthesis of fluorinated compounds for electronic display technologies.
• Polymer Modification: Employed to introduce aniline and fluorine groups into polymer chains, altering surface properties and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed reactions to create complex aromatic amines.
• Research & Development: A versatile reagent in academic and industrial R&D for exploring new fluorinated chemical entities.

Basic Information

Product Name	4-Fluoroaniline Hcl
CAS No.	2146-07-8
Molecular Formula	C6H7FN • HCl
Molecular Weight	147.58 g/mol
Synonyms	4-Fluoroaniline Hydrochloride; p-Fluoroaniline Hydrochloride; 1-Amino-4-fluorobenzene Hydrochloride; 4-Fluoro-benzenamine Hydrochloride; 4-Fluoroaniline Monohydrochloride; Aniline, 4-fluoro-, hydrochloride; Benzenamine, 4-fluoro-, hydrochloride (9CI)
EINECS	218-410-6

Quality Control

Our 4-Fluoroaniline Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	215°C - 220°C
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.