Description

(S)-(-)-2-Azetidinecarboxylic Acid CAS NO 2133-34-8 is a high-purity, non-proteinogenic amino acid derivative featuring a four-membered azetidine ring. This chiral building block is critical for introducing conformational constraints and specific stereochemistry into complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, β-lactam analogs, and other bioactive molecules.
• Medicinal Chemistry Research: Used to introduce constrained ring systems and explore structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Serves as a valuable precursor for chiral auxiliaries, ligands, and catalysts in stereoselective transformations.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides and plant growth regulators with specific modes of action.
• Peptidomimetics: Incorporated into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.

Basic Information

Product Name	(S)-(-)-2-Azetidinecarboxylic Acid
CAS No.	2133-34-8
Molecular Formula	C4H7NO2
Molecular Weight	101.10 g/mol
Synonyms	(S)-Azetidine-2-carboxylic Acid; L-Azetidine-2-carboxylic Acid; (S)-(-)-Azetidine-2-carboxylic Acid; (2S)-Azetidine-2-carboxylic Acid; Azetidine-2S-carboxylic Acid; L-2-Azetidinecarboxylic Acid; (S)-2-Azetidinecarboxylic Acid; (S)-PCA
EINECS	218-365-4

Quality Control

Our (S)-(-)-2-Azetidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation [α]20/D	-80° to -90° (c=1 in H2O)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.