Description

Z-Lys(Z)-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of Nα-Carbobenzyloxy-L-lysine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of lysine residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, APIs, and biochemical tools. The product is supplied under the identifier CAS No. 2116-82-7.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester for the site-specific introduction of lysine with orthogonal side-chain protection.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Linker Chemistry: Used to create peptide-protein conjugates, antibody-drug conjugates (ADCs), and other biomolecular constructs.
• Research & Development: Essential for academic and industrial R&D focused on peptide hormones, antimicrobial peptides, and diagnostic probes.
• Custom Peptide Manufacturing: Employed by CROs and CDMOs for the reliable, large-scale production of custom peptide sequences.
• Biochemical Tool Development: Used in the synthesis of enzyme substrates, inhibitors, and affinity ligands for proteomics research.

Basic Information

Product Name	Z-Lys(Z)-Onp
CAS No.	2116-82-7
Molecular Formula	C₂₁H₂₅N₃O₇
Molecular Weight	431.44 g/mol
Synonyms	Nα-Carbobenzyloxy-Nε-carbobenzyloxy-L-lysine p-nitrophenyl ester; Nα,Nε-Bis(benzyloxycarbonyl)-L-lysine 4-nitrophenyl ester; Z-Lys(Z)-ONp; (S)-2-(((Benzyloxy)carbonyl)amino)-6-(((benzyloxy)carbonyl)amino)hexanoic acid 4-nitrophenyl ester; Boc-Lys(Z)-ONp (common misnomer); CBZ-L-Lys(CBZ)-ONp; Nα-CBZ-Nε-CBZ-L-lysine ONp ester
EINECS	Contact for details

Quality Control

Our Z-Lys(Z)-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.