Description

Methyl-(3-Trifluoromethyl-Phenyl)-Amine is a versatile aromatic amine derivative featuring a trifluoromethyl substituent, which imparts unique electronic and steric properties. This compound serves as a critical building block in advanced organic synthesis, enabling the development of molecules with enhanced biological activity and material characteristics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Material Science: Building block for advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing character.
• Dye & Pigment Manufacturing: Intermediate for producing specialized dyes and pigments with improved lightfastness and color properties.
• Research & Development: Valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Serves as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to create complex biaryl amines.

Basic Information

Product Name	Methyl-(3-Trifluoromethyl-Phenyl)-Amine
CAS No.	2026-70-2
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	N-Methyl-3-(trifluoromethyl)aniline; 3-(Trifluoromethyl)-N-methylaniline; N-Methyl-α,α,α-trifluoro-m-toluidine; m-(Trifluoromethyl)-N-methylaniline; 3-Trifluoromethyl-N-methylaniline; N-Methyl-3-trifluoromethylaniline; 1-Methylamino-3-trifluoromethylbenzene; (3-Trifluoromethylphenyl)methylamine
EINECS	217-975-8

Quality Control

Our production of Methyl-(3-Trifluoromethyl-Phenyl)-Amine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed via GC/HPLC, NMR, and mass spectrometry to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality system is designed to support cGMP and ISO 9001 standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.