Description

1-Methyl-5-(2-Fluorophenyl)-7-Fluoro-1,3-Dihydro-2H-1,4-Benzodiazepine-2-One is a high-purity, fluorinated benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for synthesizing novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the discovery and production of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical research for developing potential anxiolytic, sedative, or anticonvulsant drug candidates.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacological properties.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry Development: Utilized in scaling up and optimizing synthetic routes for cost-effective and robust API manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-Methyl-5-(2-Fluorophenyl)-7-Fluoro-1,3-Dihydro-2H-1,4-Benzodiazepine-2-One
CAS No.	2024-34-2
Molecular Formula	C₁₆H₁₂F₂N₂O
Molecular Weight	286.28 g/mol
Synonyms	7-Fluoro-1-methyl-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1-Methyl-7-fluoro-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Fluorinated Benzodiazepine Derivative; 1,4-Benzodiazepine-2-one, 1-methyl-5-(2-fluorophenyl)-7-fluoro-1,3-dihydro-; Research Compound 2024-34-2
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(2-Fluorophenyl)-7-Fluoro-1,3-Dihydro-2H-1,4-Benzodiazepine-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and current industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.