Description

2-Mercapto-L-Histidine is a sulfur-containing derivative of the essential amino acid L-histidine, featuring a thiol (-SH) functional group. This unique structure makes it a valuable biochemical building block and a potential precursor for synthesizing specialized peptides and enzyme inhibitors. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery, biochemical research, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the research and development of novel drug candidates, particularly those targeting enzyme regulation.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the role of histidine and thiol groups in protein function and catalysis.
• Peptide Synthesis: Acts as a modified amino acid residue for introducing thiol functionality into synthetic peptides, enabling disulfide bridge formation or site-specific conjugation.
• Chelating Agent Precursor: Utilized in the development of metal-chelating ligands due to the combined nitrogen and sulfur donor atoms in its structure.
• Antioxidant Research: Studied for its potential antioxidant properties stemming from its mercapto group, relevant in models of oxidative stress.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	2-Mercapto-L-Histidine
CAS No.	2002-22-4
Molecular Formula	C6H9N3O2S
Molecular Weight	187.22 g/mol
Synonyms	L-2-Mercaptohistidine; (2S)-2-Amino-3-(2-sulfanyl-1H-imidazol-4-yl)propanoic acid; 2-Thio-L-histidine; 2-Sulfanyl-L-histidine; 2-Mercaptohistidine; 2-Thiolhistidine; NSC 113979; L-Histidine, 2-mercapto-
EINECS	Contact for details

Quality Control

Our 2-Mercapto-L-Histidine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets rigorous research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.