Description

4-Oxo-Proline is a high-purity, non-proteinogenic amino acid derivative with significant utility in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and intermediate for the development of novel bioactive molecules, including peptide mimetics and enzyme inhibitors. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking to innovate in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly protease inhibitors and other targeted therapeutics.
• Peptide Chemistry: Used in the design and synthesis of modified peptides and peptidomimetics to enhance stability, bioavailability, or biological activity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Asymmetric Synthesis: Acts as a versatile starting material or auxiliary for constructing stereochemically defined molecules.
• Cosmetic Actives: Investigated for use in the formulation of advanced skincare products targeting collagen synthesis and skin repair.
• Agrochemical Development: Serves as a precursor in the research and development of new, more effective crop protection agents.

Basic Information

Product Name	4-Oxo-Proline
CAS No.	2002-02-0
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	Pyroglutamic Acid; 5-Oxoproline; L-Pyroglutamic Acid; (S)-Pyroglutamic Acid; 2-Pyrrolidone-5-carboxylic Acid; PCA; 5-Oxo-D-proline; Glutimic Acid; Pyroglutamate
EINECS	217-877-4

Quality Control

Our 4-Oxo-Proline is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and residual solvent analysis, in line with ICH guidelines. A Certificate of Analysis (COA) is supplied with each batch, and we can support development with custom grades to meet specific pharmaceutical or research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.