Description

2H-Pyrazolo[3,4-D]Pyrimidine (8Ci,9Ci) is a high-purity heterocyclic organic compound, serving as a critical advanced pharmaceutical intermediate and versatile chemical building block. Its fused pyrazolo-pyrimidine core structure is essential for synthesizing a wide range of bioactive molecules, particularly in medicinal chemistry. This compound is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs), especially for oncology and antiviral applications.
• Medicinal Chemistry Research: Serves as a privileged scaffold for designing and optimizing new drug candidates in high-throughput screening and lead optimization programs.
• Kinase Inhibitor Development: Core structure used in the creation of potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Agrochemical Synthesis: Intermediate for developing novel pesticides and herbicides with specific modes of action.
• Biochemical Tool Compound: Used in academic and industrial research to study enzyme mechanisms and cellular signaling pathways.
• Material Science: Potential building block for organic electronic materials and ligands in catalytic systems.

Basic Information

Product Name	2H-Pyrazolo[3,4-D]Pyrimidine (8Ci,9Ci)
CAS No.	271-78-3
Molecular Formula	C5H4N4
Molecular Weight	120.11 g/mol
Synonyms	2H-Pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine; Pyrazolo[3,4-d]pyrimidine; 271-78-3; 8CI,9CI; NSC 51143; CCRIS 5951; BRN 0111981; AI3-01198
EINECS	205-983-3

Quality Control

Our 2H-Pyrazolo[3,4-D]Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.