Description

Boc-His-Gly-Oh is a protected tripeptide derivative featuring a tert-butoxycarbonyl (Boc) group on the histidine residue and a free carboxylic acid terminus. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential construction of custom peptides, particularly those containing histidine.
• Pharmaceutical Research: Used in the R&D of peptide-based drugs targeting various diseases, including metabolic disorders and cancer.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Biochemical Reagent: Employed in enzymatic studies and as a substrate or inhibitor analog in protease research.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Fundamental tool for studying peptide structure, function, and interactions in university and institutional labs.

Basic Information

Product Name	Boc-His-Gly-Oh
CAS No.	1998701-32-8
Molecular Formula	C14H22N4O5
Molecular Weight	326.35 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-histidylglycine; Boc-L-histidylglycine; Boc-His-Gly-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1H-imidazol-5-yl)propanoic acid; N-Boc-L-histidylglycine; Boc-His-Gly; BOC-HIS-GLY-OH; tert-Butyloxycarbonyl-histidyl-glycine
EINECS	Contact for details

Quality Control

Our Boc-His-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and MS. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20.0° to -24.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.