Description

H-D-Asn(Trt)-Otbu·Hcl is a protected amino acid derivative, specifically an N-terminal Boc-protected asparagine analog with side-chain trityl (Trt) protection. This compound is a critical building block in the solid-phase peptide synthesis (SPPS) of complex peptides and biopharmaceuticals, where it provides orthogonal protection strategies to prevent unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, peptidomimetics, and research biochemicals.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of therapeutic peptides and peptide-based drugs.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid building block in Fmoc/t-Bu and Boc/Bzl strategies.
• Bioconjugation & Labeling: Serves as a precursor for creating site-specifically modified peptides for diagnostic or targeting applications.
• Research & Development: Employed in academic and industrial R&D for exploring new peptide structures and biological activities.
• Peptidomimetic Design: Integral for creating stable, bioavailable analogs of natural peptides in drug discovery programs.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new bioactive compounds.

Basic Information

Product Name	H-D-Asn(Trt)-Otbu·Hcl
CAS No.	1998701-13-5
Molecular Formula	C32H35ClN2O4
Molecular Weight	547.09 g/mol
Synonyms	H-D-Asparagine(Trt)-OtBu hydrochloride; Boc-D-Asn(Trt)-OH·HCl; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[(tritylamino)carbonyl]propanoic acid hydrochloride; tert-Butyl N-[(2R)-1-hydroxy-3-(tritylamino)-1-oxopropan-2-yl]carbamate hydrochloride; Boc-D-Asparagine(Trityl)-OH hydrochloride; Boc-D-Asn(Trt)-OtBu·HCl; Nα-Boc-Nβ-trityl-D-asparagine tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Asn(Trt)-Otbu·Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.