Description

n-Fmoc-5-Chloro-3-Fluoro-L-Phenylalanine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise structural control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for creating peptide libraries and therapeutic candidates with enhanced stability and bioactivity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Peptidomimetic Research: Used to incorporate halogenated phenylalanine analogs into peptide chains to study structure-activity relationships (SAR) and improve metabolic stability.
• Bioconjugation and Labeling: The Fmoc protecting group allows for orthogonal deprotection strategies, facilitating site-specific modifications.
• Chemical Biology Probes: Enables the creation of tagged or modified peptides for studying protein-protein interactions and cellular processes.
• Antibody-Drug Conjugate (ADC) Linker/Payload Development: Can be integrated into specialized linkers or peptide-based warheads for targeted cancer therapies.

Basic Information

Product Name	n-Fmoc-5-Chloro-3-Fluoro-L-Phenylalanine
CAS No.	1998650-51-3
Molecular Formula	C24H19ClFNO4
Molecular Weight	439.86 g/mol
Synonyms	Fmoc-5-Chloro-3-fluoro-L-phenylalanine; Fmoc-3-Fluoro-5-chloro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-chloro-3-fluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(5-chloro-3-fluorophenyl)propanoic acid; 5-Chloro-3-fluoro-L-phenylalanine, N-Fmoc derivative; Fmoc-Phe(3-F-5-Cl)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-5-Chloro-3-Fluoro-L-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.