Description

L-Tyrosine,n-((9H-Fluoren-9-Ylmethoxy)Carbonyl)-3-Fluoro-o-M CAS NO 1998639-29-4 is a specialized, fluorinated Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a modified tyrosine residue with a fluorine atom at the meta-position, enabling precise structural and functional modulation in synthetic peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and medicinal chemistry, particularly for creating peptide-based therapeutics, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key fluorinated Fmoc-amino acid for the automated synthesis of custom peptides with enhanced stability or specific binding properties.
• Medicinal Chemistry & Drug Discovery: Used to incorporate fluorinated tyrosine analogs into lead compounds to study structure-activity relationships (SAR), improve metabolic stability, or modulate pharmacokinetics.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescently labeled or affinity-tagged peptides for imaging, diagnostics, and target identification studies.
• Chemical Biology Research: Enables the study of enzyme mechanisms, protein-protein interactions, and post-translational modifications by providing site-specifically modified peptide sequences.
• Pharmaceutical Intermediate: A high-purity intermediate in the multi-step synthesis of complex peptide active pharmaceutical ingredients (APIs) for clinical trials and commercial production.

Basic Information

Product Name	L-Tyrosine,n-((9H-Fluoren-9-Ylmethoxy)Carbonyl)-3-Fluoro-o-M
CAS No.	1998639-29-4
Molecular Formula	C25H20FNO5
Molecular Weight	433.43 g/mol
Synonyms	Fmoc-3-fluoro-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-L-tyrosine; Fmoc-Tyr(3-F)-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3-fluoro-4-hydroxyphenyl)propanoic acid; 3-Fluoro-L-tyrosine, N-Fmoc derivative; Fmoc-3-F-Tyr-OH; Fmoc-3F-Y-OH; Fmoc-L-Tyr(3-F)-OH
EINECS	Contact for details

Quality Control

Our L-Tyrosine,n-((9H-Fluoren-9-Ylmethoxy)Carbonyl)-3-Fluoro-o-M is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity, correct stereochemistry, and consistent performance in sensitive synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.