Description

n-Fmoc-S-(Trifluoromethyl)-L-Cysteine is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for introducing the unique S-(trifluoromethyl)cysteine moiety, which imparts enhanced metabolic stability, altered lipophilicity, and improved binding characteristics to target biomolecules. It is an essential building block for pharmaceutical researchers and peptide chemists developing novel therapeutics, diagnostic agents, and biochemical probes, particularly in the fields of oncology, neurology, and infectious diseases. The product is supplied to meet the stringent purity requirements of modern drug discovery and development pipelines.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the precise incorporation of a trifluoromethylthioether side chain into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide-based drug candidates where the CF3-S group is leveraged to modulate pharmacokinetic properties, such as membrane permeability and metabolic resistance.
• Chemical Biology & Probe Development: Facilitates the creation of activity-based probes and labeled peptides for studying enzyme mechanisms and protein-protein interactions.
• Bioconjugation: Serves as a precursor for developing novel linkers and functionalized peptides for antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Material Science: Potential use in creating novel peptidomimetic polymers and surfaces with specific chemical and physical properties derived from the fluorine content.

Basic Information

Product Name	n-Fmoc-S-(Trifluoromethyl)-L-Cysteine
CAS No.	1994331-25-7
Molecular Formula	C₂₁H₂₀F₃NO₄S
Molecular Weight	439.44 g/mol
Synonyms	Fmoc-Cys(SCF3)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(trifluoromethyl)-L-cysteine; Fmoc-S-trifluoromethyl-L-cysteine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[(trifluoromethyl)sulfanyl]propanoic acid; N-α-Fmoc-S-(trifluoromethyl)cysteine; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(trifluoromethyl)-; Fmoc-Cys(SCF3)-OH (protected amino acid); Fmoc-L-Cys(SCF3)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-S-(Trifluoromethyl)-L-Cysteine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.