Description

Teplow'S Amyloid B-Protein (1-40) (Scrambled Ii) Trifluoroacetate is a synthetic peptide analog of the amyloid β-protein, specifically designed as a scrambled sequence control for critical Alzheimer's disease research. This high-purity compound is essential for validating the specificity of assays and experiments targeting the aggregation and neurotoxicity of native Aβ peptides. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative disease mechanisms and therapeutic discovery.

Application

• Negative Control in Alzheimer's Disease Research: Serves as a critical scrambled-sequence control in studies investigating the aggregation kinetics, toxicity, and biochemical properties of native Aβ(1-40).
• Assay Validation & Specificity Testing: Used to validate the specificity of immunoassays (ELISA, Western Blot), binding assays, and cellular toxicity assays designed for amyloid-beta detection.
• Drug Discovery Screening: Employed as a control compound in high-throughput screening (HTS) campaigns to identify inhibitors of Aβ aggregation, ensuring hits are sequence-specific.
• Biophysical Studies: Provides a non-aggregating reference in biophysical characterization techniques such as circular dichroism (CD), nuclear magnetic resonance (NMR), and surface plasmon resonance (SPR).
• Antibody & Diagnostic Reagent Development: Crucial for testing the specificity of monoclonal and polyclonal antibodies intended for research or diagnostic use against amyloid-beta epitopes.
• Teaching & Method Standardization: Used in academic settings to teach principles of peptide chemistry, protein aggregation, and controlled experimental design.

Basic Information

Product Name	Teplow'S Amyloid B-Protein (1-40) (Scrambled Ii) Trifluoroacetate
CAS No.	1987844-71-2
Molecular Formula	C194H295N55O58 • xC2HF3O2
Molecular Weight	~4329.8 g/mol (free base)
Synonyms	Aβ(1-40) Scrambled Control; Amyloid β-Protein (1-40) Scrambled Sequence; Scrambled Aβ(1-40); Teplow's Scrambled Aβ40; Scrambled Amyloid Beta (1-40) Peptide; Aβ1-40 Scrambled; Scrambled Isoform II of Amyloid Beta Peptide 1-40
EINECS	Contact for details

Quality Control

Every batch of our Amyloid B-Protein (1-40) (Scrambled Ii) Trifluoroacetate is manufactured and tested under stringent quality systems suitable for research and development use. We provide comprehensive analytical data to ensure identity, purity, and consistency batch-to-batch. Certificates of Analysis (COA) detailing purity by HPLC, mass spectrometry (MS) confirmation, and amino acid analysis (AAA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass confirmed by ESI-TOF or MALDI-TOF
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 70% (by AAA)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.