Description

1-(5-Bromopyrimidin-2-yl)piperidin-4-amine dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrimidine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in drug discovery programs, particularly those focused on kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities.
• Bioconjugation & Probe Development: Serves as a starting material for creating biochemical probes and labeled compounds for biological assays.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up synthesis under cGMP conditions for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	1-(5-Bromopyrimidin-2-yl)piperidin-4-amine dihydrochloride
CAS No.	1986404-69-6
Molecular Formula	C9H14BrCl2N5
Molecular Weight	338.05 g/mol
Synonyms	1-(5-Bromopyrimidin-2-yl)-4-piperidinamine dihydrochloride; 4-Amino-1-(5-bromopyrimidin-2-yl)piperidine dihydrochloride; 1-(5-Bromo-2-pyrimidinyl)-4-piperidinamine dihydrochloride; 1-(5-Bromopyrimidin-2-yl)piperidin-4-amine hydrochloride (1:2); 1986404-69-6; 5-Bromo-2-(4-aminopiperidin-1-yl)pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(5-Bromopyrimidin-2-yl)piperidin-4-amine dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.