Description

4-(Difluoromethyl)Aniline Hydrochloride is a specialized fluorinated aromatic amine salt, serving as a critical building block in advanced organic synthesis. Its value lies in the introduction of the difluoromethyl group, a key motif for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoromethyl group can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic diamines and other components used in electronic display technologies and organic light-emitting diodes.
• Functional Material Development: Employed in the synthesis of specialty polymers, dyes, and pigments where fluorine substitution imparts unique chemical and physical properties.
• Cross-Coupling Reactions: Acts as a protected aniline derivative in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex nitrogen-containing heterocycles.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D laboratories exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	4-(Difluoromethyl)Aniline Hydrochloride
CAS No.	1980063-54-4
Molecular Formula	C7H8ClF2N
Molecular Weight	179.59 g/mol
Synonyms	4-(Difluoromethyl)benzenamine hydrochloride; 4-Aminobenzylidene difluoride hydrochloride; 1-Amino-4-(difluoromethyl)benzene hydrochloride; Benzenamine, 4-(difluoromethyl)-, hydrochloride; p-(Difluoromethyl)aniline hydrochloride; 4-(Difluoromethyl)phenylamine hydrochloride; Aniline, 4-(difluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethyl)Aniline Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent in-house specifications, which are aligned with industry best practices for high-value chemical intermediates. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.