Description

Fmoc-4-Fluoro-n-Methyl-L-Phenylalanine CAS NO 1979176-87-8 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a fluorinated, N-methylated phenylalanine residue, which can significantly enhance the metabolic stability, bioavailability, and binding affinity of therapeutic peptides. It is an essential building block for pharmaceutical researchers and manufacturers developing next-generation peptide-based drugs, including oncology treatments, hormone analogs, and targeted therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy in automated peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide active pharmaceutical ingredients (APIs) with improved pharmacokinetic profiles.
• Peptidomimetic Design: Incorporates fluorine and N-methylation to create peptide mimics resistant to enzymatic degradation.
• Chemical Biology Probes: Serves as a building block for labeled peptides used in drug discovery and mechanism-of-action studies.
• Antibody-Drug Conjugate (ADC) Linker-Payload Systems: Can be utilized in the synthesis of complex peptide linkers or as part of the cytotoxic payload.
• Combinatorial Chemistry Libraries: Provides structural diversity in high-throughput screening libraries for identifying new lead compounds.

Basic Information

Product Name	Fmoc-4-Fluoro-n-Methyl-L-Phenylalanine
CAS No.	1979176-87-8
Molecular Formula	C26H24FNO4
Molecular Weight	433.47 g/mol
Synonyms	Fmoc-4-Fluoro-N-methyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-N-methyl-L-phenylalanine; Fmoc-N-Me-4-F-Phe-OH; Fmoc-N-Methyl-4-fluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-fluorophenyl)-2-methylpropanoic acid; N-Fmoc-4-fluoro-N-methyl-L-phenylalanine; N-α-Fmoc-N-methyl-4-fluoro-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-4-Fluoro-n-Methyl-L-Phenylalanine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), chiral purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.