Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 6-Acetyl-2-[[5-(4-Acetyl-1-Piperazinyl)-2-Pyridinyl]Amino]-8-Cyclopentyl-5-Methyl- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of targeted therapeutic agents. This compound is critical for research and development in medicinal chemistry, offering a sophisticated molecular scaffold for kinase inhibition studies. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel oncology and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitor candidates for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of drug molecules.
• Preclinical Development: Serves as a critical material for producing batches of active pharmaceutical ingredients (APIs) for in-vitro and in-vivo testing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client drug discovery programs.
• Academic Research: Utilized in university and institutional labs for fundamental research on pyridopyrimidine-based signaling pathways.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial manufacturing of complex drug substances.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 6-Acetyl-2-[[5-(4-Acetyl-1-Piperazinyl)-2-Pyridinyl]Amino]-8-Cyclopentyl-5-Methyl-
CAS No.	1974279-20-3
Molecular Formula	C28H34N6O3
Molecular Weight	502.61 g/mol
Synonyms	6-Acetyl-2-[[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]amino]-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one; 8-Cyclopentyl-5-methyl-6-acetyl-2-[(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one; 1974279-20-3; UNII-7V8W34R1QN; 7V8W34R1QN; 6-Acetyl-8-cyclopentyl-5-methyl-2-({5-[4-(acetyl)piperazin-1-yl]pyridin-2-yl}amino)pyrido[2,3-d]pyrimidin-7(8H)-one
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-7(8H)-One intermediate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.