Description

(1R)-2,2,2-Trifluoro-1-(4-Methoxyphenyl)Ethylamine is a high-purity chiral amine building block of significant importance in modern synthetic chemistry. Its value lies in its trifluoromethyl group and chiral center, which are critical for modulating the biological activity and metabolic stability of advanced pharmaceutical compounds. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and fluorinated polymers with unique properties.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of fluorinated fine chemicals.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-(4-Methoxyphenyl)Ethylamine
CAS No.	1961245-70-4
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	(R)-1-(4-Methoxyphenyl)-2,2,2-trifluoroethanamine; (1R)-1-(4-Methoxyphenyl)-2,2,2-trifluoroethanamine; (R)-α-(Trifluoromethyl)-4-methoxybenzylamine; (R)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanamine; (R)-TFMPEA; (R)-1-(4-Methoxyphenyl)-2,2,2-trifluoroethylamine; (R)-4-Methoxy-α-(trifluoromethyl)benzylamine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-(4-Methoxyphenyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for advanced synthetic intermediates. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.