Description

n-Fmoc-7-Fluoro-L-Tryptophan is a high-purity, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a modified tryptophan residue with enhanced properties. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic research laboratories developing novel therapeutic peptides, peptidomimetics, and biochemical probes. The introduction of fluorine at the 7-position of the indole ring can significantly alter the electronic properties, metabolic stability, and binding affinity of the resulting peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of complex peptide chains.
• Pharmaceutical Research: Used in the discovery and development of fluorinated peptide-based drugs, where the fluorine atom can improve bioavailability, target selectivity, and in vivo stability.
• Chemical Biology & Proteomics: Serves as a tool for site-specific labeling, structure-activity relationship (SAR) studies, and the creation of peptide libraries for screening.
• Agrochemical Peptide Development: Employed in research for novel bioactive peptides with potential applications in crop protection.
• Diagnostic Reagent Synthesis: A key intermediate in the production of specialized peptides used in diagnostic assays and imaging agents.
• Academic & Institutional Research: Essential for fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Item	Detail
Product Name	n-Fmoc-7-Fluoro-L-Tryptophan
CAS No.	1956434-65-3
Molecular Formula	C₂₆H₂₁FN₂O₄
Molecular Weight	444.46 g/mol
Synonyms	Fmoc-7-F-Trp-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(7-fluoro-1H-indol-3-yl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-fluoro-L-tryptophan; 7-Fluoro-L-tryptophan, N-Fmoc derivative; Fmoc-7-fluoro-L-Trp; N-α-Fmoc-7-fluoro-L-tryptophan; Fmoc-7-F-L-Trp-OH; Fmoc-7-Fluoro-L-Trp
EINECS	Contact for details

Quality Control

Our n-Fmoc-7-Fluoro-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards. Specifications are designed to meet the rigorous demands of GMP-grade peptide synthesis and advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.