Description

5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-2-Ol Hydrochloride is a high-purity pharmaceutical intermediate and research chemical with the CAS number 1956321-99-5. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for projects targeting kinase inhibition and other critical biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a scaffold or building block for designing and optimizing new chemical entities (NCEs) in drug discovery programs.
• Kinase Inhibitor Development: Particularly valuable in the research and development of small-molecule kinase inhibitors due to its pyridopyrimidine core structure.
• Biochemical Assays: Employed as a standard or reference compound in high-throughput screening (HTS) and in vitro biological testing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and novel synthetic methodologies.

Basic Information

Product Name	5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-2-Ol Hydrochloride
CAS No.	1956321-99-5
Molecular Formula	C7H10N3O•HCl
Molecular Weight	187.63 g/mol (Free base: 152.18 g/mol)
Synonyms	2-Hydroxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride; 5,6,7,8-Tetrahydro-2-pyridopyrimidin-2-ol hydrochloride; THPP-HCl; Pyrido[4,3-d]pyrimidin-2(1H)-one, 5,6,7,8-tetrahydro-, hydrochloride; 1956321-99-5
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-2-Ol Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.