Description

3-Hydroxy-Dl-Proline Hydrochloride is a chemically modified derivative of the amino acid proline, presented as its hydrochloride salt for enhanced stability and handling. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is essential for research and production in medicinal chemistry, peptide synthesis, and biochemical studies, where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for drugs targeting collagen-related disorders or requiring hydroxyproline motifs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified proline residues, influencing peptide conformation and biological activity.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, metabolic pathway analysis, and as a probe for studying collagen biosynthesis and degradation.
• Organic Synthesis: Employed as a versatile building block for the synthesis of complex natural products, heterocyclic compounds, and specialty fine chemicals.
• Cosmeceutical Research: Investigated for potential use in anti-aging and skin repair formulations due to its structural relationship to hydroxyproline, a major component of skin collagen.

Basic Information

Product Name	3-Hydroxy-Dl-Proline Hydrochloride
CAS No.	1956319-64-4
Molecular Formula	C5H9NO3 • HCl
Molecular Weight	167.59 g/mol (Free base) / 204.05 g/mol (Hydrochloride)
Synonyms	DL-3-Hydroxyproline Hydrochloride; (±)-3-Hydroxyproline Hydrochloride; 3-Hydroxy-DL-proline HCl; trans-3-Hydroxy-DL-proline Hydrochloride; (RS)-3-Hydroxypyrrolidine-2-carboxylic acid hydrochloride; 3-Hydroxy-2-pyrrolidinecarboxylic acid hydrochloride; Allo-3-hydroxy-DL-proline hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-Dl-Proline Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets stringent specifications for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.