Description

3-Fluoro-2-Methoxyaniline Hydrochloride is a high-purity, functionalized aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a reactive aromatic amine handle with orthogonal fluorine and methoxy substituents, enabling precise molecular design and diversification. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-donating properties.
• Dye and Pigment Manufacturing: Intermediate for synthesizing complex azo dyes and organic pigments where specific color fastness and spectral properties are required.
• Cross-Coupling Reactions: Valuable substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to construct complex biaryl amines.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and fluorescent tags for biochemical and diagnostic applications.

Basic Information

Product Name	3-Fluoro-2-Methoxyaniline Hydrochloride
CAS No.	1951439-40-9
Molecular Formula	C7H9FNO•HCl
Molecular Weight	177.61 g/mol (Free base: 141.15 g/mol)
Synonyms	2-Methoxy-3-fluoroaniline hydrochloride; 3-Fluoro-2-methoxybenzenamine hydrochloride; 3-Fluoro-o-anisidine hydrochloride; 2-Amino-6-fluoroanisole hydrochloride; 1-Amino-3-fluoro-2-methoxybenzene hydrochloride; Benzenamine, 3-fluoro-2-methoxy-, hydrochloride; 3-Fluoro-2-methoxyphenylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Methoxyaniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.