Description

1-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3,3-Difluorocyclobutane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorocyclobutane scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in peptide mimetics and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptidomimetic Chemistry: Used to incorporate the rigid, polar difluorocyclobutane motif into peptide backbones, improving proteolytic stability and pharmacokinetic properties.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a specialized linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying enzyme function and protein-protein interactions.
• Fmoc-Protected Amino Acid Analogue: Functions as a protected, fluorinated non-proteinogenic amino acid for solid-phase peptide synthesis (SPPS).
• Material Science Research: Potential monomer for creating specialized polymers with unique fluorine-containing properties.

Basic Information

Product Name	1-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3,3-Difluorocyclobutane-1-Carboxylic Acid
CAS No.	1936532-04-5
Molecular Formula	C20H17F2NO4
Molecular Weight	373.35 g/mol
Synonyms	Fmoc-3,3-difluoro-1-aminocyclobutane-1-carboxylic acid; 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluorocyclobutane-1-carboxylic acid; Fmoc-Amf(F2)-OH; Fmoc-1-amino-3,3-difluorocyclobutane-1-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-difluoro-1-aminocyclobutanecarboxylic acid; 3,3-Difluoro-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}cyclobutane-1-carboxylic acid; 1-{[(Fmoc)amino]-3,3-difluorocyclobutane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3,3-Difluorocyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.