Description

2,4-Difluoro-5-Iodophenol is a halogenated phenol derivative that serves as a versatile and high-value synthetic intermediate. Its unique structure, featuring iodine and fluorine substituents, makes it a critical building block for constructing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of active ingredients, as well as by material scientists exploring novel functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the difluoro and iodo groups enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Material Science Research: Building block for synthesizing advanced polymers, liquid crystals, and organic electronic materials requiring halogenated aromatic units.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	2,4-Difluoro-5-Iodophenol
CAS No.	1935521-44-0
Molecular Formula	C6H3F2IO
Molecular Weight	271.99 g/mol
Synonyms	5-Iodo-2,4-difluorophenol; 2,4-Difluoro-5-iodo-1-hydroxybenzene; 1-Hydroxy-2,4-difluoro-5-iodobenzene; Phenol, 2,4-difluoro-5-iodo-; 2,4-DFIP; 5-Iodo-2,4-DFP
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Iodophenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR are available for each lot and provided upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.