Description

Fmoc-A-Methyl-(S)-3-Cyclohexylalanine CAS NO 1934266-55-3 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This chiral building block is critical for introducing sterically hindered, hydrophobic cyclohexylalanine analogs into peptide chains, enabling the development of novel bioactive compounds with enhanced metabolic stability and binding affinity. It is an essential reagent for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on peptide-based drug discovery, proteomics, and the synthesis of complex peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides and peptide libraries.
• Medicinal Chemistry & Drug Discovery: For the rational design and synthesis of peptide therapeutics, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Peptidomimetic Development: To create stable peptide analogs with improved pharmacokinetic properties by incorporating the α-methylated, cyclohexyl-substituted side chain.
• Bioconjugation & Probe Synthesis: In the preparation of labeled peptides for diagnostic imaging, target identification, and biochemical assays.
• Academic & Industrial Research: For fundamental studies in organic synthesis, stereochemistry, and the structure-activity relationships (SAR) of peptides.

Basic Information

Product Name	Fmoc-A-Methyl-(S)-3-Cyclohexylalanine
CAS No.	1934266-55-3
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-α-Me-(S)-Cha-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-(S)-3-cyclohexylalanine; Fmoc-(α-methyl)cyclohexylalanine; Fmoc-α-methyl-3-cyclohexyl-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-3-cyclohexylpropanoic acid; Fmoc-A-Me-Cha-OH; Fmoc-α-Me-Cha-OH; Nα-Fmoc-α-methyl-3-cyclohexyl-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-A-Methyl-(S)-3-Cyclohexylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.