Description

Fmoc-N-Me-D-Met-OH is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a methylated methionine residue with D-configuration into peptide chains, enabling the creation of novel structures with enhanced metabolic stability and specific biological activity. It is an essential building block for pharmaceutical researchers and manufacturers developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, specifically for incorporating N-methyl-D-methionine.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with improved bioavailability, receptor selectivity, and resistance to enzymatic degradation.
• Bioconjugation and Labeling: Serves as a precursor for synthesizing custom amino acids for site-specific protein modification or fluorescent labeling.
• Antimicrobial Peptide (AMP) Research: Facilitates the development of novel AMPs with modified backbones to combat antibiotic resistance.
• Chemical Biology Probes: Enables the study of protein-protein interactions and enzyme mechanisms through the incorporation of tailored methionine derivatives.
• GPCR-targeted Therapeutics: Used in the synthesis of constrained peptides targeting G-protein-coupled receptors for metabolic, neurological, and oncological indications.

Basic Information

Product Name	Fmoc-N-Me-D-Met-OH
CAS No.	1932384-22-9
Molecular Formula	C₂₁H₂₃NO₄S
Molecular Weight	385.48 g/mol
Synonyms	Fmoc-N-methyl-D-methionine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-methionine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-(methylthio)butanoic acid; Fmoc-N-Me-D-Met; Fmoc-N-Methyl-D-methionine; Fmoc-D-N-methylmethionine; N-Fmoc-N-methyl-D-methionine; N-α-Fmoc-N-α-methyl-D-methionine
EINECS	Contact for details

Quality Control

Our Fmoc-N-Me-D-Met-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm D-configuration, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.