Description

Fmoc-R-(Me)Ala(3-F3)-Oh is a non-natural, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is engineered to introduce unique steric and electronic properties into peptide chains, significantly enhancing their metabolic stability and binding affinity. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key fluorinated monomer for the Fmoc-strategy synthesis of complex peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to improve resistance to enzymatic degradation and enhance target selectivity.
• Chemical Biology & Proteomics: Used to create labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Development: Potential application in the design of bioactive peptides with enhanced stability for crop protection.
• Material Science: Building block for the synthesis of specialized peptidomimetics and functional polymers.

Basic Information

Product Name	Fmoc-R-(Me)Ala(3-F3)-Oh
CAS No.	1932361-33-5
Molecular Formula	C20H18F3NO4
Molecular Weight	393.36 g/mol
Synonyms	Fmoc-(R)-3-(Trifluoromethyl)-N-methylalanine; Fmoc-N-Me-3-CF3-D-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-3-(trifluoromethyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(trifluoromethyl)propanoic acid; Fmoc-N-methyl-3-trifluoromethyl-D-alanine; Fmoc-D-N-Me-CF3-Ala-OH; N-Fmoc-N-methyl-3-(trifluoromethyl)-D-alanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-R-(Me)Ala(3-F3)-Oh is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting purity (HPLC), chiral purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.