Description

Fmoc-D-Alb-Oh CAS NO 1932248-63-9 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of the non-proteinogenic amino acid 2-aminoisobutyric acid (Alb) into peptide chains, enabling the creation of peptides with enhanced metabolic stability and unique conformational properties. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of complex peptides.
• Pharmaceutical Research: For the development of therapeutic peptides with improved stability against enzymatic degradation.
• Peptidomimetic Design: To introduce conformational constraints and create foldamers or helical structures in synthetic peptides.
• Bioconjugation & Labeling: Serves as a specialized intermediate for creating labeled peptides for diagnostic or imaging applications.
• Academic & Institutional R&D: Used in laboratories studying protein folding, structure-activity relationships (SAR), and novel biomaterials.
• Contract Manufacturing (CDMO): A critical raw material for the GMP-scale production of peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-D-Alb-Oh
CAS No.	1932248-63-9
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-D-2-aminoisobutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-aminoisobutyric acid; Fmoc-D-Aib-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid; Fmoc-D-α-aminoisobutyric acid; N-Fmoc-D-2-methylalanine; Fmoc-D-2-methylalanine; Fmoc-D-Alb-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Alb-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for peptide synthesis. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing purity, chiral integrity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.