Description

Ghrelin-Cys(Bmcc-Biotinyl) (Human) Trifluoroacetate Salt is a chemically modified, biotinylated derivative of the human appetite-regulating hormone ghrelin. This compound is specifically engineered for advanced research applications, enabling high-sensitivity detection and isolation through biotin-streptavidin interaction technology. It is an essential tool for researchers in endocrinology, metabolic disease studies, and pharmaceutical development who require precise molecular probes for receptor binding assays, signal transduction pathway analysis, and biomarker discovery.

Application

• Biochemical Research & Receptor Binding Studies: Used as a high-affinity probe for investigating the ghrelin receptor (GHSR-1a) in vitro.
• Pull-Down Assays & Protein Interaction Mapping: The biotin tag facilitates the isolation and identification of ghrelin-binding proteins and receptor complexes using streptavidin-coated beads.
• Diagnostic Assay Development: Serves as a critical component in the development of sensitive ELISA, chemiluminescence, or lateral flow immunoassays for ghrelin pathway analysis.
• Metabolic Disorder Research: A key reagent in studies focused on appetite regulation, obesity, diabetes, and cachexia.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel agonists or antagonists of the ghrelin pathway.
• Cell Signaling & Imaging: Utilized in fluorescence-activated cell sorting (FACS) and microscopy when conjugated to fluorescently labeled streptavidin for cellular localization studies.

Basic Information

Product Name	Ghrelin-Cys(Bmcc-Biotinyl) (Human) Trifluoroacetate Salt
CAS No.	1927927-44-3
Molecular Formula	C179H284N52O53S2 • xC2HF3O2
Molecular Weight	~4040.6 g/mol (Free base, excluding TFA salt)
Synonyms	Human Ghrelin (Biotinylated); Biotinyl-Ghrelin (Human); Ghrelin (1-28)-Cys(Biotin), human; Biotin-labeled Ghrelin; Ghrelin-Biotin Conjugate; Appetite-regulating Hormone Biotin Derivative; GHS (Biotin); [Cys28(Biotin)]Ghrelin (human)
EINECS	Contact for details

Quality Control

Our Ghrelin-Cys(Bmcc-Biotinyl) (Human) Trifluoroacetate Salt is manufactured under strict quality systems suitable for research use. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, Mass Spectrometry (MS) for identity confirmation, and Amino Acid Analysis (AAA). We adhere to relevant guidelines for peptide synthesis to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Trifluoroacetate (TFA) Content	≤ 15% (by HPLC/IC)
Biological Activity	Determined by receptor binding assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.