Description

Fmoc-β-Azido-D-Aib-Oh·Bha≥ 99% (At,Hplc) is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and chemical biology research. This compound is critical for introducing the unique β-azido and 2-aminoisobutyric acid (Aib) motifs into peptide chains, enabling the creation of structurally constrained peptides and facilitating bioorthogonal click chemistry. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of novel peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides containing Aib and azido-functionalized side chains.
• Bioorthogonal Chemistry: The azido group enables efficient Cu(I)-catalyzed or strain-promoted azide-alkyne cycloaddition (Click Chemistry) for site-specific bioconjugation and labeling of biomolecules.
• Peptidomimetic Drug Discovery: Incorporation of the Aib residue induces helical conformations and enhances metabolic stability, making it valuable for developing peptide-based drug candidates.
• Chemical Biology Probes: Used to synthesize activity-based probes (ABPs) or affinity tags for studying enzyme function and protein-protein interactions.
• Material Science: Serves as a monomer for creating functionalized polymers or surfaces with bioactive peptide sequences.
• Antibiotic Research: Useful in synthesizing analogs of natural peptide antibiotics that contain Aib residues, such as alamethicin.

Basic Information

Product Name	Fmoc-β-Azido-D-Aib-Oh·Bha≥ 99% (At,Hplc)
CAS No.	1926163-91-8
Molecular Formula	C₂₀H₁₉N₅O₄
Molecular Weight	393.40 g/mol
Synonyms	Fmoc-β-Azido-D-Aib-OH; Fmoc-D-Aib(β-N₃)-OH; N-(9-Fluorenylmethoxycarbonyl)-β-azido-D-2-aminoisobutyric acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-azido-2-methylpropanoic acid; Fmoc-D-α-methyl-β-azido-alanine; Fmoc-D-Aib(N₃)-OH; Fmoc-D-2-amino-3-azido-2-methylpropanoic acid; Fmoc-D-β-azido-Aib-OH
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. The specified purity of ≥99% is verified by orthogonal analytical methods including HPLC and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is easily oxidized and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.