Description

H-Val-Ile-His-Thr-Edans Acetate Salt is a synthetic peptide derivative of significant interest in advanced biochemical research and development. This compound serves as a critical tool molecule, particularly valued for its role as a specialized substrate or intermediate in enzymatic studies and assay development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on protease activity, fluorescence-based detection systems, and novel therapeutic discovery. The product is supplied as an acetate salt to enhance stability and solubility for experimental use.

Application

• Protease & Enzyme Substrate: Used as a specialized fluorogenic or chromogenic peptide substrate for studying enzyme kinetics, specificity, and inhibition of proteases like trypsin, thrombin, or other serine proteases.
• Biochemical Assay Development: Serves as a key component in developing high-throughput screening (HTS) assays and diagnostic tests for detecting enzymatic activity in research and clinical settings.
• Pharmaceutical Research: Employed as an intermediate or reference standard in drug discovery programs targeting protease-related pathways for conditions such as thrombosis, inflammation, and cancer.
• Peptide Chemistry & Synthesis: Acts as a building block or model compound for studying peptide structure-activity relationships (SAR) and for the synthesis of more complex peptide conjugates.
• Cell Biology Studies: Utilized in cellular imaging and activity-based protein profiling (ABPP) to visualize and quantify protease function within live cells or tissue samples.

Basic Information

Product Name	H-Val-Ile-His-Thr-Edans Acetate Salt
CAS No.	1926163-43-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Val-Ile-His-Thr-Edans acetate; Edans-labeled peptide V-I-H-T; Fluorogenic peptide substrate V-I-H-T-Edans; H-Val-Ile-His-Thr-EDANS acetate salt; 5-((2-Aminoethyl)amino)naphthalene-1-sulfonyl-Val-Ile-His-Thr-OH acetate; Protease substrate VIHT-Edans; EDANS-VIHT-OH acetate
EINECS	Contact for details

Quality Control

Our H-Val-Ile-His-Thr-Edans Acetate Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to minimize condensation and exposure to atmospheric moisture. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/Titration)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.