Description

Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-Oh is a specialized, high-purity tetrapeptide building block featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group and a C-terminal carboxylic acid. This compound is critical for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, particularly those requiring a polyproline helix structure or D-amino acid sequences. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid sequence for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Probe Development: Serves as a scaffold for creating labeled peptides for imaging, diagnostic assays, and targeted drug delivery systems.
• Structural Biology Studies: Employed to synthesize model peptides for studying polyproline type II (PPII) helices and the effects of D-amino acids on peptide conformation and stability.
• Peptidomimetic Design: A building block for creating non-natural peptide analogs with enhanced metabolic stability and bioavailability.
• Biochemical Reagent Production: Used to manufacture high-value reagents for cell signaling research, protein-protein interaction studies, and substrate profiling.

Basic Information

Product Name	Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-Oh
CAS No.	1926163-34-9
Molecular Formula	C49H52N4O11
Molecular Weight	873.0 g/mol
Synonyms	Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-OH; Fmoc-D-Pro4-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-prolyl-D-prolyl-D-prolyl-D-proline; Fmoc-D-Pro-Pro-Pro-Pro-OH (all-D); (All-D)-Fmoc-tetraproline; Fmoc-(D-Pro)4-OH; Tetrapeptide Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-Oh; Fmoc-D-Prolyl-D-Prolyl-D-Prolyl-D-Proline
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates and GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.