Description

α-Conotoxin Ei (Free Acid) CAS NO 1926163-14-5 is a synthetic peptide toxin derived from the venom of marine cone snails, specifically engineered in its free acid form for research and development applications. This compound is a highly selective and potent antagonist of specific nicotinic acetylcholine receptor (nAChR) subtypes, making it a critical tool for neurological research. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies focused on developing novel therapeutics for pain management, neurological disorders, and as a molecular probe for receptor characterization.

Application

• Neuroscience Research: As a selective pharmacological probe for studying the function and distribution of specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes in the central and peripheral nervous systems.
• Drug Discovery & Development: A key reference standard and lead compound in the development of new non-opioid analgesics and therapeutics for neuropathic pain.
• Pharmacology Studies: Used in in vitro and in vivo assays to investigate receptor-ligand interactions, signal transduction pathways, and the physiological roles of nAChRs.
• Biochemical Tool: Employed in binding assays, electrophysiology experiments, and structural biology studies to understand ion channel gating and inhibition mechanisms.
• Toxicology & Venom Research: Serves as a reference material for studying the mechanisms of conotoxin action and for the development of antivenoms or diagnostic tools.

Basic Information

Product Name	α-Conotoxin Ei (Free Acid)
CAS No.	1926163-14-5
Molecular Formula	C58H86N18O19S5
Molecular Weight	1443.7 g/mol
Synonyms	α-Conotoxin EI; α-Conotoxin EI free acid; Conotoxin EI; α-Conotoxin EI (free acid); EI Conotoxin; Acetylcholine receptor antagonist EI; α-CTx EI; Alpha conotoxin EI peptide; 1926163-14-5; UNII-9G2H6IWM0K
EINECS	Contact for details

Quality Control

Every batch of α-Conotoxin Ei (Free Acid) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from multiple orthogonal methods such as HPLC, MS, and amino acid analysis. Our quality commitment aligns with standards suitable for research and pre-clinical development, ensuring reliable and reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%
Biological Activity	Confirmed by functional assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.