Description

(Des-Ser3)-Acth (1-24) (Human, Bovine, Rat) is a synthetic adrenocorticotropic hormone (ACTH) fragment analog, a critical research-grade peptide used in endocrinology and neuroscience studies. This compound matters for its specific biological activity, allowing researchers to investigate adrenal cortex function and the hypothalamic-pituitary-adrenal (HPA) axis with high precision. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel therapeutics for stress-related disorders, metabolic conditions, and adrenal insufficiency.

Application

• Endocrinology Research: Fundamental studies on adrenal gland stimulation and corticosteroid synthesis.
• Neuroscience & Behavioral Studies: Investigation of the HPA axis response to stress in animal models (rat, bovine, human-relevant systems).
• Pharmaceutical Development: Serving as a reference standard or active ingredient in pre-clinical research for new ACTH-based therapies.
• Biochemical Assay Development: Used as a calibrated ligand in receptor binding assays and activity tests.
• Metabolic Disorder Research: Exploring the role of ACTH in conditions like Addison's disease and Cushing's syndrome.
• Veterinary Research: Application in bovine and other animal health studies related to adrenal function.

Basic Information

Product Name	(Des-Ser3)-Acth (1-24) (Human, Bovine, Rat)
CAS No.	1926163-12-3
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₉S
Molecular Weight	2934.4 g/mol
Synonyms	Des-Serine³-ACTH (1-24); ACTH (1-24) (Des-Ser³); Adrenocorticotropic Hormone Fragment (1-24), Des-Ser³ analog; Cosyntropin analog; Tetracosactide derivative; Synacthen fragment analog; Research ACTH fragment; H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH (with Ser³ deletion)
EINECS	Contact for details

Quality Control

Our (Des-Ser3)-Acth (1-24) is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to stringent analytical standards, utilizing techniques like HPLC and mass spectrometry to verify the product meets specified research-grade criteria.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store the lyophilized powder under desiccant and, upon reconstitution, use immediately or aliquot and store frozen under inert atmosphere for short-term stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.