Description

Fmoc-Asp(Otbu)-Cys(Psi(Me,Me)Pro)-Oh≥ 99% (Hplc,Tlc) is a high-purity, protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers developing complex peptide-based pharmaceuticals, where precise sequence control and high coupling efficiency are paramount. It is specifically engineered for the synthesis of peptides containing pseudoproline dipeptide mimetics, which are essential for overcoming challenging sequences and improving synthetic yields. This product is indispensable for R&D and production in pharmaceutical, biotechnology, and academic laboratories focused on novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected dipeptide unit for the Fmoc/tBu strategy, enabling the efficient assembly of complex peptide chains.
• Peptidomimetic Drug Discovery: Used to incorporate the Cys(Psi(Me,Me)Pro) pseudoproline motif, which is crucial for inducing specific turns, improving solubility, and preventing aggregation during synthesis of therapeutic peptide candidates.
• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Labeling: The protected aspartic acid side chain (OtBu) and cysteine thiol (protected as a pseudoproline) provide orthogonal protection for subsequent site-specific modifications or fluorescent labeling.
• Research & Development: Essential for academic and industrial research into peptide structure-activity relationships (SAR), folding studies, and the development of new synthetic methodologies.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening to identify novel bioactive compounds.

Basic Information

Product Name	Fmoc-Asp(Otbu)-Cys(Psi(Me,Me)Pro)-Oh≥ 99% (Hplc,Tlc)
CAS No.	1926163-09-8
Molecular Formula	C₃₃H₄₃N₃O₈S
Molecular Weight	641.78 g/mol
Synonyms	Fmoc-Asp(OtBu)-Cys(ψMe,Mepro)-OH; Fmoc-L-Asp(OtBu)-L-Cys(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-tert-butyl ester-L-cysteine(ψMe,Meproline) peptide; Fmoc-Asp(OtBu)-Cys(ψMe,Mepro)-OH; Fmoc-Asp(OtBu)-Cys(Psi(Me,Me)Pro)-OH; Protected Pseudoproline Dipeptide; Fmoc-Asp(OtBu)-Cys(ψMe,Mepro)-OH; SPPS Building Block
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Asp(Otbu)-Cys(Psi(Me,Me)Pro)-Oh is manufactured and tested under strict quality management systems. The guaranteed purity of ≥99% is verified by orthogonal analytical methods including High-Performance Liquid Chromatography (HPLC) and Thin-Layer Chromatography (TLC). Our quality control protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP guidelines for advanced intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 99.0%
Purity (TLC)	Single spot
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.