Description

Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)Pro)-Oh CAS NO 1926163-07-6 is a specialized, high-purity pseudoproline-containing dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to address critical challenges in the synthesis of complex or difficult peptide sequences by minimizing aggregation and improving coupling efficiency. It is an essential reagent for research and development scientists in pharmaceutical discovery, biotechnology, and academic institutions working on novel therapeutic peptides, peptidomimetics, and protein engineering.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the Fmoc/t-Bu strategy, facilitating the synthesis of challenging sequences prone to aggregation.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Incorporation of the pseudoproline dipeptide induces turns and disrupts secondary structure, aiding in the creation of stable, bioactive mimetics.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Protein Engineering: Serves as a key intermediate for site-specific modifications and the synthesis of engineered proteins with novel functionalities.
• Academic & Institutional Research: A fundamental tool for studying peptide structure-activity relationships, folding mechanisms, and biochemical pathways.

Basic Information

Item	Detail
Product Name	Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)Pro)-Oh
CAS No.	1926163-07-6
Molecular Formula	C41H56N4O9S
Molecular Weight	780.98 g/mol
Synonyms	Fmoc-Lys(Boc)-Cys(ψMe,Mepro)-OH; N-α-Fmoc-N-ε-Boc-L-lysyl-S-(2,2-dimethyl-1,3-thiazolidin-4-carbonyl)-L-cysteine; Fmoc-Lys(Boc)-Cys(ψ(Me,Mepro))-OH; Pseudoproline Dipeptide Fmoc-Lys(Boc)-Cys; Fmoc-Lys(Boc)-Cys(ψ(Dmp,H)Pro)-OH; Fmoc-L-Lys(Boc)-L-Cys(ψMe,Mepro)-OH; (2S)-2-[(2S)-6-[(2-Methylpropan-2-yl)oxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanamido]-3-[(4R)-2,2-dimethyl-1,3-thiazolidine-4-carbonothioyl]sulfanylpropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)Pro)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Assay	≥ 97.0% (by NMR)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.